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FrontPageBets studies prospects for Clemson's regular-season win total

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Clemson-Different Spring Football

Clemson head coach Dabo Swinney and the Tigers are looking to rebound this season after going 10-3 in 2021, missing the ACC title game and the College Football Playoff for the first time since 2014.

Clemson is the odds-on favorite this season to win the Atlantic Coast Conference by a significant margin.

The Tigers are -120 to return to tops in the league after falling off last year, going 10-3 and missing out on the conference title game and the College Football Playoffs for the first time since 2014.

Ready to rebound, Clemson’s regular-season win total for the 2022 season is set at 10.5, according to DraftKings. Odds the Tigers will win more than 10.5 games is set at +110, while the under is -130.

FrontPageBets takes a look at Clemson’s regular-season schedule with predictions and some key games that will determine if they can get to 11 victories.

2022 overview

For Clemson, it all starts under center.

The question is, will quarterback D.J. Uiagalelei live up to the hype he had last year coming into the season? As the signal-caller who replaced former top NFL Draft pick Trevor Lawrence, Uiagalelei struggled with an average (by its standards) offensive performance last season, throwing more interceptions (10) than touchdown passes (9), while completing just 55% of his throws.

If Uiagalelei can’t make it happen, the Tigers have five-star, true freshman Cade Klubnik waiting in the wings.

Defensively, Clemson should be solid, returning a lot of key fixtures who finished last season No. 2 in scoring defense (14.9 points per game) and eighth in total defense (305.5 ypg).

The Tigers will have new coordinators on both sides of the ball, however. Brandon Streeter takes over on offense for former OC Tony Elliott, who left to become the head coach at Virginia. Wes Goodwin will have some big shoes to fill at defensive coordinator, replacing Brent Venables, who now is the head coach at Oklahoma.

Key games to determining O/U 10.5 victories: Wake Forest, N.C. State and South Carolina

At Wake Forest, Sept. 24

Even more so than the road trip to South Bend, Ind., to face Notre Dame in November, Clemson’s journey to face Wake Forest in Winston-Salem, N.C., will be the biggest test in a young season.

Sure, Clemson opens the season in Atlanta against Georgia Tech on Sept. 5, but there might be more orange and purple-clad fans in Mercedes-Benz Stadium that the Ramblin’ Wreck will have, leaving the game at Wake as the Tigers’ first “true” road game.

Coming off an Atlantic Division title last year, the Demon Deacons have some key returners, including quarterback Sam Hartman, who set a Wake Forest single-season record for passing yards with 4,228. He is also the program’s all-time leader in touchdown passes with 72.

Vs. North Carolina State, Oct. 1

A week after traveling to Wake Forest, Clemson returns to Death Valley to play what should be a very good N.C. State team.

The Wolfpack returns an ACC-leading 17 starters, including quarterback Devin Leary, who set a single-season N.C. State record with 35 touchdown passes last year.

It’s the first ACC home game for Clemson and the last home game before back-to-back weeks on the road to Boston College and Florida State, respectively.

Vs. South Carolina, Nov. 26

The thing about rivalry games is momentum.

The game against South Carolina is the third of three consecutive home games for Clemson to end the regular season. And if things go Clemson’s way during the season, which has some tough games on the road, the game against the Gamecocks could be the difference between 10 and 11 wins, putting the Tigers at the magic number.

Leaving little room for error, Clemson will have to contend with a South Carolina squad that will be better in Shane Beamer’s second year. That includes stopping former Oklahoma star quarterback Spencer Rattler, who is getting some preseason Heisman Trophy hype.

Clemson’s 2022 regular-season schedule breakdown

Sept. 5 at Georgia Tech (Mercedes-Benz Stadium, Atlanta): W

Sept. 10 vs. Furman: W

Sept. 17 vs. La. Tech: W

Sept. 24 at Wake Forest: W

Oct. 1 vs. N.C. State: L

Oct. 8 at Boston College: W

Oct. 15 at Florida State: W

Oct. 22 vs. Syracuse: W

Nov. 5 at Notre Dame: W

No. 12 vs. Louisville: W

Nov. 18 vs. Miami: W

Nov. 26 vs. South Carolina: L

Prediction: 10-2

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Mike Szvetitz is the General Manager and Content Director for Szvetitz is a 22-year veteran reporter and editor, including serving 17 years as a sports editor in Florida, Alabama and Virginia, covering everything from preps to pros. His "View From The Lazy Boy" column won multiple state and national awards. He can be reached at


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